What is Glycolysis? Explain the Phases of Glycose oxidative pathway at cellular levels?
Glycolysis literally means “splitting of sugar“. The pathway is also called “EMP Pathway” and “Glucose oxidative pathway“. In glycolysis, Glucose (a six-carbon sugar) is split into two molecules of three-carbon sugar. Glycolysis yields two molecules of ATP (free energy containing molecule), two molecules of pyruvic acid and two “high energy” electron carrying molecules of NADH. Glycolysis can occur with or without oxygen. In the presence of oxygen, glycolysis is the first stage of cellular respiration. Without oxygen, glycolysis allows cells to make small amounts of ATP. This process is called fermentation.
Phases and Stages of Glycolysis
In summary, a single glucose molecule in glycolysis produces a total of 2 molecules of pyruvic acid, 2 molecules of ATP, 2 molecules of NADH and 2 molecules of water.
Although 2 ATP molecules are used in steps 1-3, 2 ATP molecules are generated in step 7 and 2 more in step 10. This gives a total of 4 ATP molecules produced. If you subtract the 2 ATP molecules used in steps 1-3 from the 4 generated at the end of step 10, you end up with a net total of 2 ATP molecules produced. For a detailed view of the 10 steps, see: Details of the 10 Steps of Glycolysis.